Bayern Munich will not only have to overturn a 3-0 Champions League semi-final first leg deficit against Barcelona on Tuesday but they will have to do it against a superb defence and in the midst of their biggest slump in years.
Messi stretched Barca's lead by finishing off a brilliant move with Luis Suarez in the 50th minute and the Uruguayan joined his close friend and strike partner on 15 league goals by robbing an Eibar defender and finishing inside the near post in the 68th.
Real Madrid beat Leganes 4-2 on Wednesday despite resting key players including Cristiano Ronaldo and Gareth Bale as goals from Alvaro Morata and James Rodriguez helped them stay top of La Liga after Barcelona cruised to a 3-0 win over Sevilla.
IMAGES from the football matches played across Europe on Sunday.
When Barcelona host local rivals Espanyol on Saturday hoping to edge closer to the La Liga title, many may be haunted by Raul Tamudo's 89th minute equaliser which wrecked their title bid in 2006/07.
Barcelona need to avoid getting sucked into the Spanish obsession with El Clasico when they face Ajax Amsterdam in the Champions League on Tuesday.
Lionel Messi will have another chance to match or surpass Telmo Zarra's six-decade-old La Liga scoring record of 251 goals when Barcelona host promoted Eibar on Saturday.
Real Madrid thrashed Deportivo La Coruna 6-2 to stay level with Barcelona at the top of La Liga on Wednesday after the Catalans crushed Osasuna 7-1, condemning the minnows to relegation.
Images from the Nations League matches played on Thursday.
Barcelona closed in on the La Liga title by thrashing local rivals Espanyol 5-0 on Sunday as Atletico Madrid dropped out of the race after losing 2-1 at Levante and Real Madrid beat Valencia 3-2.
Lionel Messi, Luis Suarez and Neymar combined to devastating effect as Barcelona swatted Celtic aside 7-0 at the Nou Camp to lay down a marker in Champions League Group C on Tuesday.
Barcelona followed up Saturday's win over Real Madrid with another victory when Alexis Sanchez set the champions on their way to a 3-0 success at Celta Vigo on Tuesday that put them four points clear at the top of La Liga.
Now, Real Madrid have never won the Spanish treble and are fighting tooth and nail in La Liga to prevent arch-rivals Barcelona scooping Champions League and domestic league and Cup titles for a second time.
With five titles, Barca are now level with AC Milan on all-time UEFA Super Cup winners list
Barcelona's hopes of staging another sensational Champions League comeback fell flat against a hardened Juventus side who held the Catalans to a 0-0 draw at the Nou Camp on Wednesday to reach the semi-finals 3-0 on aggregate.
Lionel Messi scored one penalty and missed another as his double helped Barcelona sweep Levante aside in the second half in a 4-1 victory on Sunday to maintain their perfect La Liga start.
Paris St Germain are sweating over striker Zlatan Ibrahimovic's fitness as the French champions look fragile ahead of Barcelona's visit in Champions League Group F on Tuesday.
Setien was named Barcelona coach late on Monday, tasked with the job of restoring the club's iconic passing style, but the appointment represents a huge gamble for the Catalans given the 61-year-old's lack of success at the highest level.
Spain forward Ansu Fati became the national team's youngest ever goalscorer as the 17-year-old inspired Luis Enrique's side to a resounding 4-0 win at home to Ukraine in the UEFA Nations League on Sunday.
Cristiano Ronaldo struck twice as leaders Real Madrid subdued Eibar 4-0 on Saturday while Lionel Messi set a La Liga record of 253 goals with a hat-trick in second-placed Barcelona's 5-1 rout of Sevilla.
Barcelona's preparations for next season were thrown off course on Friday when the Spanish champions unexpectedly announced coach Tito Vilanova was stepping down due to ill health.
In leading Real Madrid to their 11th European Cup less than five months after inheriting an unhappy team from Rafael Benitez, Zinedine Zidane has cemented his heroic status at the Bernabeu and appears to have assured his immediate future.
Just as he did two years ago, Sergio Ramos left his footprint all over Real Madrid's Champions League final triumph over Atletico Madrid following a turbulent 12 months.
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
Luis Suarez was incredulous after being sent off in Barcelona's thrilling King's Cup semi-final second leg with Atletico Madrid on Tuesday, ruling him out of the final in May after playing a pivotal role in getting his team there.
A summary of Sunday's action in the FIFA World Cup qualifiers across Europe.
Lionel Messi-inspired Barcelona overwhelmed Manchester City as Ivan Rakitic's strike secured a 1-0 win.
We once again present a special feature on the ten worst earthquakes that had shaken the world and caused immense damage in the past 25 years.
PV Sindhu and Kidambi Srikanth notched up contrasting wins to progress to the Round of 16, but World No. 11 H S Prannoy suffered a shock defeat to unheralded Brazilian Ygor Coelho to bow out of the World Championship.
Barcelona followed up last weekend's 3-1 defeat at Real Madrid with another reverse on Saturday, squandering a host of chances to lose 1-0 at home to Celta Vigo and handing the lead in La Liga to their arch rivals.
Fernando Torres stole the show with a dramatic double as Atletico Madrid secured a battling 2-2 draw at Real Madrid on Thursday that dumped the holders out of the King's Cup 4-2 on aggregate.
The Portuguese admitted he had over-stretched himself after having knee problems at the back end of the last season which he carried into the World Cup and then suffered a hamstring injury at the start of this campaign.
The result shook up League A Group 4, giving Ukraine an outside chance of finishing top of the group with two games remaining.
Struggling Rayo win at Valladolid after late penalty save
Lionel Messi reclaimed the FIFA Ballon d'Or award for the world player of the year on Monday from his great rival Cristiano Ronaldo who had walked off with the award for the previous two years.
Spain began a new era under Luis Enrique in impressive fashion as they came from a goal down to outplay England in a 2-1 win in their Nations League opener at Wembley Stadium on Saturday.
IMAGES from the 2020 Euro Qualifiers played on Monday
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
If you ask Barcelona and Spain fans about their most cherished footballing memories over the past decade the chances are they will involve an exquisite intervention from midfield maestro Xavi.
Following is reaction to the 2022 FIFA World Cup draw, which was held at the Doha Exhibition and Convention Center in Qatar on Friday.